Importance of the Proximity and Orientation of Ligand-Linkage to the Design of Cinnamate-GW9662 Hybrid Compounds as Covalent PPARγ Agonists

Covalent agonists of PPARγ cause unique receptor conformational changes and behave as selective PPARγ modulators, whereas there are few covalent agonists other than endogenous unsaturated fatty acids metabolites. Previously, we established a cell-based strategy to identify new PPARγ ligands and synt...

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Detalles Bibliográficos
Autores principales: Utsugi, Yuki, Kobuchi, Hirona, Kawamura, Yukio, Atito, Ahmed Salahelden Aboelhamd, Nagao, Masaya, Isoda, Hiroko, Miyamae, Yusaku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571965/
https://www.ncbi.nlm.nih.gov/pubmed/31137814
http://dx.doi.org/10.3390/molecules24102019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571965/
https://www.ncbi.nlm.nih.gov/pubmed/31137814
http://dx.doi.org/10.3390/molecules24102019

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