Discovery of 2-(1-(3-(4-Chloroxyphenyl)-3-oxo- propyl)pyrrolidine-3-yl)-1H-benzo[d]imidazole-4-carboxamide: A Potent Poly(ADP-ribose) Polymerase (PARP) Inhibitor for Treatment of Cancer

A series of benzimidazole carboxamide derivatives have been synthesized and characterized by (1)H-NMR, (13)C-NMR and HRMS. PARP inhibition assays and cellular proliferation assays have also been carried out. Compounds 5cj and 5cp exhibited potential anticancer activities with IC(50) values of about...

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Detalles Bibliográficos
Autores principales: Min, Rui, Wu, Weibin, Wang, Mingzhong, Tang, Lin, Chen, Dawei, Zhao, Huan, Zhang, Cunlong, Jiang, Yuyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572064/
https://www.ncbi.nlm.nih.gov/pubmed/31108884
http://dx.doi.org/10.3390/molecules24101901

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572064/
https://www.ncbi.nlm.nih.gov/pubmed/31108884
http://dx.doi.org/10.3390/molecules24101901

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