Synthesis, Docking and Biological Evaluation of a Novel Class of Imidazothiazoles as IDO1 Inhibitors

IDO1, a key dioxygenase in tryptophan-kynurenine metabolism, appeared in the last 10 years at the vanguard of druggable targets in cancer therapy due to its well-established role both in immune escape and inflammatory neovascularization. Among the pool of IDO1 inhibitors that have entered clinical t...

Descripción completa

Detalles Bibliográficos
Autores principales: Serafini, Marta, Torre, Enza, Aprile, Silvio, Massarotti, Alberto, Fallarini, Silvia, Pirali, Tracey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572114/
https://www.ncbi.nlm.nih.gov/pubmed/31096672
http://dx.doi.org/10.3390/molecules24101874

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572114/
https://www.ncbi.nlm.nih.gov/pubmed/31096672
http://dx.doi.org/10.3390/molecules24101874

Ejemplares similares