Cargando…

Synthesis, Docking and Biological Evaluation of a Novel Class of Imidazothiazoles as IDO1 Inhibitors

IDO1, a key dioxygenase in tryptophan-kynurenine metabolism, appeared in the last 10 years at the vanguard of druggable targets in cancer therapy due to its well-established role both in immune escape and inflammatory neovascularization. Among the pool of IDO1 inhibitors that have entered clinical t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Serafini, Marta, Torre, Enza, Aprile, Silvio, Massarotti, Alberto, Fallarini, Silvia, Pirali, Tracey
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572114/ https://www.ncbi.nlm.nih.gov/pubmed/31096672 http://dx.doi.org/10.3390/molecules24101874

Ejemplares similares

The [1,2,4]Triazolo[4,3‐a]pyridine as a New Player in the Field of IDO1 Catalytic Holo‐Inhibitors
por: Fallarini, Silvia, et al.
Publicado: (2021)

Melanoma Cells Inhibit iNKT Cell Functions via PGE2 and IDO1
por: Torre, Enza, et al.
Publicado: (2023)

Isatin Bis-Indole and Bis-Imidazothiazole Hybrids: Synthesis and Antimicrobial Activity
por: Bonvicini, Francesca, et al.
Publicado: (2022)

Essential Medicinal Chemistry of Essential Medicines
por: Serafini, Marta, et al.
Publicado: (2020)

A Versatile and Sustainable Multicomponent Platform for the Synthesis of Protein Degraders: Proof-of-Concept Application to BRD4-Degrading PROTACs
por: Bhela, Irene Preet, et al.
Publicado: (2022)

Antiamoebic Activity of Imidazothiazole Derivatives against Opportunistic Pathogen Acanthamoeba castellanii
por: Akbar, Noor, et al.
Publicado: (2022)

Imidazothiazole Derivatives Exhibited Potent Effects against Brain-Eating Amoebae
por: Siddiqui, Ruqaiyyah, et al.
Publicado: (2022)

What’s in a Name? Drug Nomenclature and Medicinal Chemistry Trends using INN Publications
por: Serafini, Marta, et al.
Publicado: (2021)

Design and synthesis of novel anti-urease imidazothiazole derivatives with promising antibacterial activity against Helicobacter pylori
por: Shahin, Afnan I., et al.
Publicado: (2023)

1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry
por: Aprile, Silvio, et al.
Publicado: (2021)

An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline
por: Aprile, Silvio, et al.
Publicado: (2022)

Imidazothiazole-based potent inhibitors of V600E-B-RAF kinase with promising anti-melanoma activity: biological and computational studies
por: Anbar, Hanan S., et al.
Publicado: (2020)

QSAR-Based Models for Designing Quinazoline/Imidazothiazoles/Pyrazolopyrimidines Based Inhibitors against Wild and Mutant EGFR
por: Chauhan, Jagat Singh, et al.
Publicado: (2014)

From Bench to Bedside: What Do We Know about Imidazothiazole Derivatives So Far?
por: Guo, Mu, et al.
Publicado: (2023)

Design, synthesis and biological evaluation of erlotinib-based IDO1 inhibitors
por: Hou, Xi-xi, et al.
Publicado: (2022)

Identification of a Potent Phosphoinositide 3‐Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs
por: Pirali, Tracey, et al.
Publicado: (2017)

Store-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors
por: Serafini, Marta, et al.
Publicado: (2020)

Design, Synthesis and Biological Evaluation of Phenyl Urea Derivatives as IDO1 Inhibitors
por: Zhou, Chuan, et al.
Publicado: (2020)

The 115 Years Old Multicomponent Bargellini Reaction: Perspectives and New Applications
por: Serafini, Marta, et al.
Publicado: (2021)

A Selective ALDH1A3 Inhibitor Impairs Mesothelioma 3-D Multicellular Spheroid Growth and Neutrophil Recruitment
por: Boumya, Sara, et al.
Publicado: (2023)

IDO Targeting in Sarcoma: Biological and Clinical Implications
por: Nafia, Imane, et al.
Publicado: (2020)

Docking Studies and Molecular Dynamic Simulations Reveal Different Features of IDO1 Structure
por: Greco, Francesco Antonio, et al.
Publicado: (2016)

Tritylamine as an Ammonia Surrogate in the Ugi Reaction Provides Access to Unprecedented 5-Sulfamido Oxazoles Using Burgess-type Reagents
por: Bhela, Irene Preet, et al.
Publicado: (2021)

Novel 1,2,3-Triazole Erlotinib Derivatives as Potent IDO1 Inhibitors: Design, Drug-Target Interactions Prediction, Synthesis, Biological Evaluation, Molecular Docking and ADME Properties Studies
por: Xu, Gui-Qing, et al.
Publicado: (2022)

New Insights into IDO Biology in Bacterial and Viral Infections
por: Schmidt, Susanne V., et al.
Publicado: (2014)

Impact of IDO1 and IDO2 on the B Cell Immune Response
por: Merlo, Lauren M. F., et al.
Publicado: (2022)

N-Heterocycles Scaffolds as Quorum Sensing Inhibitors. Design, Synthesis, Biological and Docking Studies
por: Fuentes-Gutiérrez, Alfredo, et al.
Publicado: (2020)

Amyloid β neurotoxicity is IDO1–Kyn–AhR dependent and blocked by IDO1 inhibitor
por: Duan, Zhenzhen, et al.
Publicado: (2020)

Synthesis and activity study of novel N,N-diphenylurea derivatives as IDO1 inhibitors
por: Hou, Xi-Xi, et al.
Publicado: (2023)

Polyphenol Polymerization by an Alternative Oxidative Microbial Enzyme and Characterization of the Biological Activity of Oligomers
por: Di Gennaro, Patrizia, et al.
Publicado: (2018)

Indole Derivatives as Cyclooxygenase Inhibitors: Synthesis, Biological Evaluation and Docking Studies
por: Bhat, Mashooq Ahmad, et al.
Publicado: (2018)

Trial watch: IDO inhibitors in cancer therapy
por: Le Naour, Julie, et al.
Publicado: (2020)

Differential Roles of IDO1 and IDO2 in T and B Cell Inflammatory Immune Responses
por: Merlo, Lauren M. F., et al.
Publicado: (2020)

CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy
por: Cordero-Sanchez, Celia, et al.
Publicado: (2022)

Cinnamide Derivatives as Mammalian Arginase Inhibitors: Synthesis, Biological Evaluation and Molecular Docking
por: Pham, Thanh-Nhat, et al.
Publicado: (2016)

Arylaminopropanone Derivatives as Potential Cholinesterase Inhibitors: Synthesis, Docking Study and Biological Evaluation
por: Hudcová, Anna, et al.
Publicado: (2020)

First-in-Class Dual Hybrid Carbonic Anhydrase Inhibitors and Transient Receptor Potential Vanilloid 1 Agonists Revert Oxaliplatin-Induced Neuropathy
por: Angeli, Andrea, et al.
Publicado: (2023)

Genetic Polymorphisms Affecting IDO1 or IDO2 Activity Differently Associate With Aspergillosis in Humans
por: Napolioni, Valerio, et al.
Publicado: (2019)

The Indoleamine-2,3-Dioxygenase (IDO) Inhibitor 1-Methyl-D-tryptophan Upregulates IDO1 in Human Cancer Cells
por: Opitz, Christiane A., et al.
Publicado: (2011)

Aging-associated increase in indoleamine 2,3-dioxygenase (IDO) activity appears to be unrelated to the transcription of the IDO1 or IDO2 genes in peripheral blood mononuclear cells
por: Marttila, Saara, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_n6nd5nkjodvioa2v1t66b9gjlv