Exploiting the Nucleophilicity of the Nitrogen Atom of Imidazoles: One-Pot Three-Component Synthesis of Imidazo-Pyrazines

A novel one-pot multicomponent reaction to synthesize substituted imidazopyrazines is described. In brief, 1H-(imidazol-5-yl)-N-substituted methanamines react with aldehydes and isocyanides in methanol at room temperature to give imidazopyrazine derivatives in excellent yields. The imidazole nitroge...

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Detalles Bibliográficos
Autores principales: Galli, Ubaldina, Hysenlika, Rejdia, Meneghetti, Fiorella, Del Grosso, Erika, Pelliccia, Sveva, Novellino, Ettore, Giustiniano, Mariateresa, Tron, Gian Cesare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572241/
https://www.ncbi.nlm.nih.gov/pubmed/31117306
http://dx.doi.org/10.3390/molecules24101959

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572241/
https://www.ncbi.nlm.nih.gov/pubmed/31117306
http://dx.doi.org/10.3390/molecules24101959

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