Discovery of (3-Benzyl-5-hydroxyphenyl)carbamates as New Antitubercular Agents with Potent In Vitro and In Vivo Efficacy

A series of 3-amino-5-benzylphenol derivatives were designed and synthesized. Among them, (3-benzyl-5-hydroxyphenyl)carbamates were found to exert good inhibitory activity against M. tuberculosis H37Ra, H37Rv and clinically isolated multidrug-resistant M. tuberculosis strains (MIC = 0.625–6.25 μg/mL...

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Detalles Bibliográficos
Autores principales: Cheng, Ya-Juan, Liu, Zhi-Yong, Liang, Hua-Ju, Fang, Cui-Ting, Zhang, Niu-Niu, Zhang, Tian-Yu, Yan, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572244/
https://www.ncbi.nlm.nih.gov/pubmed/31137832
http://dx.doi.org/10.3390/molecules24102021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572244/
https://www.ncbi.nlm.nih.gov/pubmed/31137832
http://dx.doi.org/10.3390/molecules24102021

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