Novel Nucleic Acid Binding Small Molecules Discovered Using DNA-Encoded Chemistry

Inspired by the many reported successful applications of DNA-encoded chemical libraries in drug discovery projects with protein targets, we decided to apply this platform to nucleic acid targets. We used a 120-billion-compound set of 33 distinct DNA-encoded chemical libraries and affinity-mediated s...

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Detalles Bibliográficos
Autores principales: Litovchick, Alexander, Tian, Xia, Monteiro, Michael I., Kennedy, Kaitlyn M., Guié, Marie-Aude, Centrella, Paolo, Zhang, Ying, Clark, Matthew A., Keefe, Anthony D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572338/
https://www.ncbi.nlm.nih.gov/pubmed/31137911
http://dx.doi.org/10.3390/molecules24102026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572338/
https://www.ncbi.nlm.nih.gov/pubmed/31137911
http://dx.doi.org/10.3390/molecules24102026

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