Structure of an engineered multidrug transporter MdfA reveals the molecular basis for substrate recognition

MdfA is a prototypical H(+)-coupled multidrug transporter that is characterized by extraordinarily broad substrate specificity. The involvement of specific H-bonds in MdfA-drug interactions and the simplicity of altering the substrate specificity of MdfA contradict the promiscuous nature of multidru...

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Detalles Bibliográficos
Autores principales: Wu, Hsin-Hui, Symersky, Jindrich, Lu, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572762/
https://www.ncbi.nlm.nih.gov/pubmed/31240248
http://dx.doi.org/10.1038/s42003-019-0446-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572762/
https://www.ncbi.nlm.nih.gov/pubmed/31240248
http://dx.doi.org/10.1038/s42003-019-0446-y

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