Structural basis for the inhibition of translation through eIF2α phosphorylation

One of the responses to stress by eukaryotic cells is the down-regulation of protein synthesis by phosphorylation of translation initiation factor eIF2. Phosphorylation results in low availability of the eIF2 ternary complex (eIF2-GTP-tRNAi) by affecting the interaction of eIF2 with its GTP-GDP exch...

Descripción completa

Detalles Bibliográficos
Autores principales: Gordiyenko, Yuliya, Llácer, José Luis, Ramakrishnan, V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572841/
https://www.ncbi.nlm.nih.gov/pubmed/31201334
http://dx.doi.org/10.1038/s41467-019-10606-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572841/
https://www.ncbi.nlm.nih.gov/pubmed/31201334
http://dx.doi.org/10.1038/s41467-019-10606-1

Ejemplares similares