T-cell receptor gene therapy targeting melanoma-associated antigen-A4 by silencing of endogenous TCR inhibits tumor growth in mice and human

Genetically engineered T cells expressing a T-cell receptor (TCR) are powerful tools for cancer treatment and have shown significant clinical effects in sarcoma patients. However, mismatch of the introduced TCR α/β chains with endogenous TCR may impair the expression of transduced TCR, resulting in...

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Detalles Bibliográficos
Autores principales: Sun, Qian, Zhang, Xiying, Wang, Limei, Gao, Xujie, Xiong, Yanjuan, Liu, Liang, Wei, Feng, Yang, Lili, Ren, Xiubao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572850/
https://www.ncbi.nlm.nih.gov/pubmed/31209257
http://dx.doi.org/10.1038/s41419-019-1717-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572850/
https://www.ncbi.nlm.nih.gov/pubmed/31209257
http://dx.doi.org/10.1038/s41419-019-1717-8

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