Cargando…

T-cell receptor gene therapy targeting melanoma-associated antigen-A4 by silencing of endogenous TCR inhibits tumor growth in mice and human

Genetically engineered T cells expressing a T-cell receptor (TCR) are powerful tools for cancer treatment and have shown significant clinical effects in sarcoma patients. However, mismatch of the introduced TCR α/β chains with endogenous TCR may impair the expression of transduced TCR, resulting in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Qian, Zhang, Xiying, Wang, Limei, Gao, Xujie, Xiong, Yanjuan, Liu, Liang, Wei, Feng, Yang, Lili, Ren, Xiubao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572850/ https://www.ncbi.nlm.nih.gov/pubmed/31209257 http://dx.doi.org/10.1038/s41419-019-1717-8

Ejemplares similares

Endogenous TCR Recombination in TCR Tg Single RAG-Deficient Mice Uncovered by Robust In Vivo T Cell Activation and Selection
por: Montaudouin, Caroline, et al.
Publicado: (2010)

Single-Cell Sequencing Reveals the Transcriptome and TCR Characteristics of pTregs and in vitro Expanded iTregs
por: Hui, Zhenzhen, et al.
Publicado: (2021)

Anti-melanoma activity of T cells redirected with a TCR-like chimeric antigen receptor
por: Zhang, Ge, et al.
Publicado: (2014)

Tumor-specific donor lymphocyte infusion therapy with allogeneic T cells utilizing novel retrovirus vector silencing endogenous TCR expression
por: Ikeda, Hiroaki, et al.
Publicado: (2014)

CD147 silencing inhibits tumor growth by suppressing glucose transport in melanoma
por: Su, Juan, et al.
Publicado: (2016)

Inhibiting Delta-6 Desaturase Activity Suppresses Tumor Growth in Mice
por: He, Chengwei, et al.
Publicado: (2012)

TCR Analyses of Two Vast and Shared Melanoma Antigen-Specific T Cell Repertoires: Common and Specific Features
por: Simon, Sylvain, et al.
Publicado: (2018)

Control of T cell antigen reactivity via programmed TCR downregulation
por: Gallegos, Alena M, et al.
Publicado: (2016)

Transgenic CD8αβ co-receptor rescues endogenous TCR function in TCR-transgenic virus-specific T cells
por: Bajwa, Gagan, et al.
Publicado: (2020)

A TCR-based Chimeric Antigen Receptor
por: Walseng, Even, et al.
Publicado: (2017)

TCR-Directed Therapy in the Treatment of Metastatic Uveal Melanoma
por: Strobel, Sophia B., et al.
Publicado: (2022)

Stoichiometry of the T cell antigen receptor (TCR) complex: each TCR/CD3 complex contains one TCR alpha, one TCR beta, and two CD3 epsilon chains
Publicado: (1994)

Cish actively silences tcr signaling in CD8+ T cells to maintain tumor tolerance
por: Palmer, Douglas, et al.
Publicado: (2015)

Cish actively silences TCR signaling in CD8(+) T cells to maintain tumor tolerance
por: Palmer, Douglas C., et al.
Publicado: (2015)

A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen
por: Bianchi, Valentina, et al.
Publicado: (2016)

Biased MAIT TCR Usage Poised for Limited Antigen Diversity?
por: Souter, Michael N. T., et al.
Publicado: (2020)

Silencing and Transcriptional Regulation of Endogenous Retroviruses: An Overview
por: Geis, Franziska K., et al.
Publicado: (2020)

Profiling the dynamic expression of checkpoint molecules on cytokine-induced killer cells from non-small-cell lung cancer patients
por: Zhang, Lin, et al.
Publicado: (2016)

Selective targeting of transforming growth factor-beta1 into TCR/CD28 signalling plasma membrane domains silences T cell activation
por: Harder, Thomas, et al.
Publicado: (2014)

COX-2 Silencing in Canine Malignant Melanoma Inhibits Malignant Behaviour
por: Silveira, Tatiany L., et al.
Publicado: (2021)

A novel antibody-TCR (AbTCR) platform combines Fab-based antigen recognition with gamma/delta-TCR signaling to facilitate T-cell cytotoxicity with low cytokine release
por: Xu, Yiyang, et al.
Publicado: (2018)

Allelic Exclusion in pTα-deficient Mice: No Evidence for Cell Surface Expression of Two T Cell Receptor (TCR)-β Chains, but Less Efficient Inhibition of Endogeneous Vβ→ (D)Jβ Rearrangements in the Presence of a Functional TCR-β Transgene
por: Krotkova, Anna, et al.
Publicado: (1997)

Structure of the T cell antigen receptor (TCR): two CD3 epsilon subunits in a functional TCR/CD3 complex
Publicado: (1991)

Modifications outside CDR1, 2 and 3 of the TCR variable β domain increase TCR expression and antigen-specific function
por: Degirmencay, Abdullah, et al.
Publicado: (2023)

Tolerance in TCR/Cognate Antigen Double-Transgenic Mice Mediated by Incomplete Thymic Deletion and Peripheral Receptor Downregulation
por: Mamalaki, Clio, et al.
Publicado: (1995)

Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities
por: Van Caeneghem, Yasmine, et al.
Publicado: (2017)

High Throughput Sequencing of T Cell Antigen Receptors Reveals a Conserved TCR Repertoire
por: Hou, Xianliang, et al.
Publicado: (2016)

The TCR is randomly distributed on the plasma membrane of resting antigen-experienced T cells
por: Rossboth, Benedikt, et al.
Publicado: (2018)

Molecular Analysis of Elements of Melanoma Insensitivity to TCR-Engineered Adoptive Cell Therapy
por: Jazirehi, Ali R.
Publicado: (2021)

RNA Interference-Mediated Aurora Kinase A Gene Silencing Inhibits Human Glioma Cells Proliferation and Tumor Growth in Mice
por: Zhang, Ge, et al.
Publicado: (2021)

The tumor suppressor interferon regulatory factor 8 inhibits β-catenin signaling in breast cancers, but is frequently silenced by promoter methylation
por: Luo, Xinrong, et al.
Publicado: (2017)

Orally administered endoxifen inhibits tumor growth in melanoma-bearing mice
por: Chen, Paul, et al.
Publicado: (2018)

Babesia microti Infection Inhibits Melanoma Growth by Activating Macrophages in Mice
por: Shu, Xiang, et al.
Publicado: (2022)

Flubendazole inhibits PD-1 and suppresses melanoma growth in immunocompetent mice
por: Li, Yue, et al.
Publicado: (2023)

The Silence of PSMC6 Inhibits Cell Growth and Metastasis in Lung Adenocarcinoma
por: Zhang, Jian-Yu, et al.
Publicado: (2021)

Inhibitor of growth protein 3 epigenetically silences endogenous retroviral elements and prevents innate immune activation
por: Song, Yanhua, et al.
Publicado: (2021)

Antigen-specificity and DTIC before peptide-vaccination differently shape immune-checkpoint expression pattern, anti-tumor functionality and TCR repertoire in melanoma patients
por: Palermo, Belinda, et al.
Publicado: (2018)

Pre-TCRα and TCRα Are Not Interchangeable Partners of TCRβ during T Lymphocyte Development
por: Borowski, Christine, et al.
Publicado: (2004)

A degron system targeting endogenous PD-1 inhibits the growth of tumor cells in mice
por: Naruse, Chie, et al.
Publicado: (2022)

Structure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infection
por: Shimizu, Akihisa, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_gte3j6ufdotojimlefots5outf