Recombinant production, purification, crystallization, and structure analysis of human transforming growth factor β2 in a new conformation

Transforming growth factor β is a disulfide-linked dimeric cytokine that occurs in three highly related isoforms (TGFβ1–TGFβ3) engaged in signaling functions through binding of cognate TGFβ receptors. To regulate this pathway, the cytokines are biosynthesized as inactive pro-TGFβs with an N-terminal...

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Detalles Bibliográficos
Autores principales: del Amo-Maestro, Laura, Marino-Puertas, Laura, Goulas, Theodoros, Gomis-Rüth, F. Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572864/
https://www.ncbi.nlm.nih.gov/pubmed/31209258
http://dx.doi.org/10.1038/s41598-019-44943-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572864/
https://www.ncbi.nlm.nih.gov/pubmed/31209258
http://dx.doi.org/10.1038/s41598-019-44943-4

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