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Recombinant production, purification, crystallization, and structure analysis of human transforming growth factor β2 in a new conformation
Transforming growth factor β is a disulfide-linked dimeric cytokine that occurs in three highly related isoforms (TGFβ1–TGFβ3) engaged in signaling functions through binding of cognate TGFβ receptors. To regulate this pathway, the cytokines are biosynthesized as inactive pro-TGFβs with an N-terminal...
Autores principales: | del Amo-Maestro, Laura, Marino-Puertas, Laura, Goulas, Theodoros, Gomis-Rüth, F. Xavier |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572864/ https://www.ncbi.nlm.nih.gov/pubmed/31209258 http://dx.doi.org/10.1038/s41598-019-44943-4 |
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