High-Order Epistasis in Catalytic Power of Dihydrofolate Reductase Gives Rise to a Rugged Fitness Landscape in the Presence of Trimethoprim Selection

Evolutionary fitness landscapes of several antibiotic target proteins have been comprehensively mapped showing strong high-order epistasis between mutations, but understanding these effects at the biochemical and structural levels remained open. Here, we carried out an extensive experimental and com...

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Detalles Bibliográficos
Autores principales: Tamer, Yusuf Talha, Gaszek, Ilona K, Abdizadeh, Haleh, Batur, Tugce Altinusak, Reynolds, Kimberly A, Atilgan, Ali Rana, Atilgan, Canan, Toprak, Erdal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6573477/
https://www.ncbi.nlm.nih.gov/pubmed/30982891
http://dx.doi.org/10.1093/molbev/msz086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6573477/
https://www.ncbi.nlm.nih.gov/pubmed/30982891
http://dx.doi.org/10.1093/molbev/msz086

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