Cargando…

High-Order Epistasis in Catalytic Power of Dihydrofolate Reductase Gives Rise to a Rugged Fitness Landscape in the Presence of Trimethoprim Selection

Evolutionary fitness landscapes of several antibiotic target proteins have been comprehensively mapped showing strong high-order epistasis between mutations, but understanding these effects at the biochemical and structural levels remained open. Here, we carried out an extensive experimental and com...

Descripción completa

Detalles Bibliográficos
Autores principales: Tamer, Yusuf Talha, Gaszek, Ilona K, Abdizadeh, Haleh, Batur, Tugce Altinusak, Reynolds, Kimberly A, Atilgan, Ali Rana, Atilgan, Canan, Toprak, Erdal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6573477/
https://www.ncbi.nlm.nih.gov/pubmed/30982891
http://dx.doi.org/10.1093/molbev/msz086