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NAD(+)-dependent RNA terminal 2′ and 3′ phosphomonoesterase activity of a subset of Tpt1 enzymes
The enzyme Tpt1 removes the 2′-PO(4) at the splice junction generated by fungal tRNA ligase; it does so via a two-step reaction in which (i) the internal RNA 2′-PO(4) attacks NAD(+) to form an RNA-2′-phospho-ADP-ribosyl intermediate; and (ii) transesterification of the ribose O2″ to the 2′-phosphodi...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6573784/ https://www.ncbi.nlm.nih.gov/pubmed/31019096 http://dx.doi.org/10.1261/rna.071142.119 |