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Antagonism between the RNA-binding protein Musashi1 and miR-137 and its potential impact on neurogenesis and glioblastoma development
RNA-binding proteins (RBPs) and miRNAs are critical gene expression regulators that interact with one another in cooperative and antagonistic fashions. We identified Musashi1 (Msi1) and miR-137 as regulators of a molecular switch between self-renewal and differentiation. Msi1 and miR-137 have opposi...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6573790/ https://www.ncbi.nlm.nih.gov/pubmed/31004009 http://dx.doi.org/10.1261/rna.069211.118 |
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author | Velasco, Mitzli X. Kosti, Adam Guardia, Gabriela D.A. Santos, Marcia C. Tegge, Allison Qiao, Mei Correa, Bruna R.S. Hernández, Greco Kokovay, Erzsebet Galante, Pedro A.F. Penalva, Luiz O.F. |
author_facet | Velasco, Mitzli X. Kosti, Adam Guardia, Gabriela D.A. Santos, Marcia C. Tegge, Allison Qiao, Mei Correa, Bruna R.S. Hernández, Greco Kokovay, Erzsebet Galante, Pedro A.F. Penalva, Luiz O.F. |
author_sort | Velasco, Mitzli X. |
collection | PubMed |
description | RNA-binding proteins (RBPs) and miRNAs are critical gene expression regulators that interact with one another in cooperative and antagonistic fashions. We identified Musashi1 (Msi1) and miR-137 as regulators of a molecular switch between self-renewal and differentiation. Msi1 and miR-137 have opposite expression patterns and functions, and Msi1 is repressed by miR-137. Msi1 is a stem–cell protein implicated in self-renewal while miR-137 functions as a proneuronal differentiation miRNA. In gliomas, miR-137 functions as a tumor suppressor while Msi1 is a prooncogenic factor. We suggest that the balance between Msi1 and miR-137 is a key determinant in cell fate decisions and disruption of this balance could contribute to neurodegenerative diseases and glioma development. Genomic analyses revealed that Msi1 and miR-137 share 141 target genes associated with differentiation, development, and morphogenesis. Initial results pointed out that these two regulators have an opposite impact on the expression of their target genes. Therefore, we propose an antagonistic model in which this network of shared targets could be either repressed by miR-137 or activated by Msi1, leading to different outcomes (self-renewal, proliferation, tumorigenesis). |
format | Online Article Text |
id | pubmed-6573790 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-65737902020-07-01 Antagonism between the RNA-binding protein Musashi1 and miR-137 and its potential impact on neurogenesis and glioblastoma development Velasco, Mitzli X. Kosti, Adam Guardia, Gabriela D.A. Santos, Marcia C. Tegge, Allison Qiao, Mei Correa, Bruna R.S. Hernández, Greco Kokovay, Erzsebet Galante, Pedro A.F. Penalva, Luiz O.F. RNA Report RNA-binding proteins (RBPs) and miRNAs are critical gene expression regulators that interact with one another in cooperative and antagonistic fashions. We identified Musashi1 (Msi1) and miR-137 as regulators of a molecular switch between self-renewal and differentiation. Msi1 and miR-137 have opposite expression patterns and functions, and Msi1 is repressed by miR-137. Msi1 is a stem–cell protein implicated in self-renewal while miR-137 functions as a proneuronal differentiation miRNA. In gliomas, miR-137 functions as a tumor suppressor while Msi1 is a prooncogenic factor. We suggest that the balance between Msi1 and miR-137 is a key determinant in cell fate decisions and disruption of this balance could contribute to neurodegenerative diseases and glioma development. Genomic analyses revealed that Msi1 and miR-137 share 141 target genes associated with differentiation, development, and morphogenesis. Initial results pointed out that these two regulators have an opposite impact on the expression of their target genes. Therefore, we propose an antagonistic model in which this network of shared targets could be either repressed by miR-137 or activated by Msi1, leading to different outcomes (self-renewal, proliferation, tumorigenesis). Cold Spring Harbor Laboratory Press 2019-07 /pmc/articles/PMC6573790/ /pubmed/31004009 http://dx.doi.org/10.1261/rna.069211.118 Text en © 2019 Velasco et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Report Velasco, Mitzli X. Kosti, Adam Guardia, Gabriela D.A. Santos, Marcia C. Tegge, Allison Qiao, Mei Correa, Bruna R.S. Hernández, Greco Kokovay, Erzsebet Galante, Pedro A.F. Penalva, Luiz O.F. Antagonism between the RNA-binding protein Musashi1 and miR-137 and its potential impact on neurogenesis and glioblastoma development |
title | Antagonism between the RNA-binding protein Musashi1 and miR-137 and its potential impact on neurogenesis and glioblastoma development |
title_full | Antagonism between the RNA-binding protein Musashi1 and miR-137 and its potential impact on neurogenesis and glioblastoma development |
title_fullStr | Antagonism between the RNA-binding protein Musashi1 and miR-137 and its potential impact on neurogenesis and glioblastoma development |
title_full_unstemmed | Antagonism between the RNA-binding protein Musashi1 and miR-137 and its potential impact on neurogenesis and glioblastoma development |
title_short | Antagonism between the RNA-binding protein Musashi1 and miR-137 and its potential impact on neurogenesis and glioblastoma development |
title_sort | antagonism between the rna-binding protein musashi1 and mir-137 and its potential impact on neurogenesis and glioblastoma development |
topic | Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6573790/ https://www.ncbi.nlm.nih.gov/pubmed/31004009 http://dx.doi.org/10.1261/rna.069211.118 |
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