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Prolonged day length exposure improves circadian deficits and survival in a transgenic mouse model of Huntington's disease
The circadian disruption seen in patients of Huntington's disease (HD) is recapitulated in the R6/2 mouse model. As the disease progresses, the activity of R6/2 mice increases dramatically during the rest (light) period and decreases during the active (dark) period, eventually leading to a comp...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6575567/ https://www.ncbi.nlm.nih.gov/pubmed/31236493 http://dx.doi.org/10.1016/j.nbscr.2016.11.004 |