Gene-edited stem cells enable CD33-directed immune therapy for myeloid malignancies

Antigen-directed immunotherapies for acute myeloid leukemia (AML), such as chimeric antigen receptor T cells (CAR-Ts) or antibody-drug conjugates (ADCs), are associated with severe toxicities due to the lack of unique targetable antigens that can distinguish leukemic cells from normal myeloid cells...

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Detalles Bibliográficos
Autores principales: Borot, Florence, Wang, Hui, Ma, Yan, Jafarov, Toghrul, Raza, Azra, Ali, Abdullah Mahmood, Mukherjee, Siddhartha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6575599/
https://www.ncbi.nlm.nih.gov/pubmed/31138698
http://dx.doi.org/10.1073/pnas.1819992116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6575599/
https://www.ncbi.nlm.nih.gov/pubmed/31138698
http://dx.doi.org/10.1073/pnas.1819992116

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