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Gene-edited stem cells enable CD33-directed immune therapy for myeloid malignancies

Antigen-directed immunotherapies for acute myeloid leukemia (AML), such as chimeric antigen receptor T cells (CAR-Ts) or antibody-drug conjugates (ADCs), are associated with severe toxicities due to the lack of unique targetable antigens that can distinguish leukemic cells from normal myeloid cells...

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Detalles Bibliográficos
Autores principales:	Borot, Florence, Wang, Hui, Ma, Yan, Jafarov, Toghrul, Raza, Azra, Ali, Abdullah Mahmood, Mukherjee, Siddhartha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2019
Materias:	PNAS Plus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6575599/ https://www.ncbi.nlm.nih.gov/pubmed/31138698 http://dx.doi.org/10.1073/pnas.1819992116

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