Extracellular interface between APP and Nicastrin regulates Aβ length and response to γ‐secretase modulators

γ‐Secretase complexes (GSECs) are multimeric membrane proteases involved in a variety of physiological processes and linked to Alzheimer's disease (AD). Presenilin (PSEN, catalytic subunit), Nicastrin (NCT), Presenilin Enhancer 2 (PEN‐2), and Anterior Pharynx Defective 1 (APH1) are the essentia...

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Detalles Bibliográficos
Autores principales: Petit, Dieter, Hitzenberger, Manuel, Lismont, Sam, Zoltowska, Katarzyna Marta, Ryan, Natalie S, Mercken, Marc, Bischoff, François, Zacharias, Martin, Chávez‐Gutiérrez, Lucía
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6576158/
https://www.ncbi.nlm.nih.gov/pubmed/31109937
http://dx.doi.org/10.15252/embj.2019101494

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6576158/
https://www.ncbi.nlm.nih.gov/pubmed/31109937
http://dx.doi.org/10.15252/embj.2019101494

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