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Deciphering regulatory DNA sequences and noncoding genetic variants using neural network models of massively parallel reporter assays
The relationship between noncoding DNA sequence and gene expression is not well-understood. Massively parallel reporter assays (MPRAs), which quantify the regulatory activity of large libraries of DNA sequences in parallel, are a powerful approach to characterize this relationship. We present MPRA-D...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6576758/ https://www.ncbi.nlm.nih.gov/pubmed/31206543 http://dx.doi.org/10.1371/journal.pone.0218073 |