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Deciphering regulatory DNA sequences and noncoding genetic variants using neural network models of massively parallel reporter assays

The relationship between noncoding DNA sequence and gene expression is not well-understood. Massively parallel reporter assays (MPRAs), which quantify the regulatory activity of large libraries of DNA sequences in parallel, are a powerful approach to characterize this relationship. We present MPRA-D...

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Detalles Bibliográficos
Autores principales:	Movva, Rajiv, Greenside, Peyton, Marinov, Georgi K., Nair, Surag, Shrikumar, Avanti, Kundaje, Anshul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6576758/ https://www.ncbi.nlm.nih.gov/pubmed/31206543 http://dx.doi.org/10.1371/journal.pone.0218073

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