DNA damage-Induced cell death relies on SLFN11-dependent cleavage of distinct type II tRNAs

Transcriptome analysis revealed a strong positive correlation between human SLFN11 expression and the sensitivity of tumor cells to DNA damaging agents (DDAs). We show here that SLFN11 preferentially inhibits translation of ATR or ATM upon DDAs treatment based on distinct codon usage without disrupt...

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Detalles Bibliográficos
Autores principales: Li, Manqing, Kao, Elaine, Malone, Dane, Gao, Xia, Wang, Jean Y. J., David, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579113/
https://www.ncbi.nlm.nih.gov/pubmed/30374083
http://dx.doi.org/10.1038/s41594-018-0142-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579113/
https://www.ncbi.nlm.nih.gov/pubmed/30374083
http://dx.doi.org/10.1038/s41594-018-0142-5

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