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DNA damage-Induced cell death relies on SLFN11-dependent cleavage of distinct type II tRNAs
Transcriptome analysis revealed a strong positive correlation between human SLFN11 expression and the sensitivity of tumor cells to DNA damaging agents (DDAs). We show here that SLFN11 preferentially inhibits translation of ATR or ATM upon DDAs treatment based on distinct codon usage without disrupt...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579113/ https://www.ncbi.nlm.nih.gov/pubmed/30374083 http://dx.doi.org/10.1038/s41594-018-0142-5 |