Age-dependent deterioration of nuclear pore assembly in mitotic cells decreases transport dynamics

Nuclear transport is facilitated by the Nuclear Pore Complex (NPC) and is essential for life in eukaryotes. The NPC is a long-lived and exceptionally large structure. We asked whether NPC quality control is compromised in aging mitotic cells. Our images of single yeast cells during aging, show that...

Descripción completa

Detalles Bibliográficos
Autores principales: Rempel, Irina L, Crane, Matthew M, Thaller, David J, Mishra, Ankur, Jansen, Daniel PM, Janssens, Georges, Popken, Petra, Akşit, Arman, Kaeberlein, Matt, van der Giessen, Erik, Steen, Anton, Onck, Patrick R, Lusk, C Patrick, Veenhoff, Liesbeth M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579512/
https://www.ncbi.nlm.nih.gov/pubmed/31157618
http://dx.doi.org/10.7554/eLife.48186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579512/
https://www.ncbi.nlm.nih.gov/pubmed/31157618
http://dx.doi.org/10.7554/eLife.48186

Ejemplares similares