HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists

Members of the nuclear receptor (NR) superfamily regulate both physiological and pathophysiological processes ranging from development and metabolism to inflammation and cancer. Synthetic small molecules targeting NRs are often deployed as therapeutics to correct aberrant NR signaling or as chemical...

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Detalles Bibliográficos
Autores principales: Strutzenberg, Timothy S, Garcia-Ordonez, Ruben D, Novick, Scott J, Park, HaJeung, Chang, Mi Ra, Doebellin, Christelle, He, Yuanjun, Patouret, Rémi, Kamenecka, Theodore M, Griffin, Patrick R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579513/
https://www.ncbi.nlm.nih.gov/pubmed/31172947
http://dx.doi.org/10.7554/eLife.47172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579513/
https://www.ncbi.nlm.nih.gov/pubmed/31172947
http://dx.doi.org/10.7554/eLife.47172

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