Semi-Mechanistic Modeling of Florfenicol Time-Kill Curves and in silico Dose Fractionation for Calf Respiratory Pathogens

An important application of time-kill curve (TKC) assays is determination of the nature of the best PK/PD index (fAUC/MIC or fT% > MIC) and its target value for predicting clinical efficacy in vivo. VetCAST (the veterinary subcommittee of EUCAST) herein presents semi-mechanistic TKC modeling for...

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Detalles Bibliográficos
Autores principales: Pelligand, Ludovic, Lees, Peter, Sidhu, Pritam Kaur, Toutain, Pierre-Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579883/
https://www.ncbi.nlm.nih.gov/pubmed/31244793
http://dx.doi.org/10.3389/fmicb.2019.01237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579883/
https://www.ncbi.nlm.nih.gov/pubmed/31244793
http://dx.doi.org/10.3389/fmicb.2019.01237

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