Cargando…

Salidroside protects SH-SY5Y from pathogenic α-synuclein by promoting cell autophagy via mediation of mTOR/p70S6K signaling

The abnormal aggregation of α-synuclein (α-syn), which is an important pathological feature of Parkinson's disease (PD), is cytotoxic to dopaminergic neurons and causes cellular damage and apoptosis. Salidroside (SAL) is the main active component of the traditional Chinese medicine Rhodiola ros...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Shasha, Cai, Feng, Wang, Jirong, Yang, Zhouxin, Gu, Chi, Wang, Guofu, Mao, Genxiang, Yan, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580031/ https://www.ncbi.nlm.nih.gov/pubmed/31180515 http://dx.doi.org/10.3892/mmr.2019.10285

Ejemplares similares

Salidroside Promotes the Pathological α-Synuclein Clearance Through Ubiquitin-Proteasome System in SH-SY5Y Cells
por: Li, Tao, et al.
Publicado: (2018)

Enterovirus 71 VP1 Protein Regulates Viral Replication in SH-SY5Y Cells via the mTOR Autophagy Signaling Pathway
por: Liu, Zi-Wei, et al.
Publicado: (2019)

Hepcidin Decreases Rotenone-Induced α-Synuclein Accumulation via Autophagy in SH-SY5Y Cells
por: Li, Meiqi, et al.
Publicado: (2020)

Andrographolide attenuates bupivacaine-induced cytotoxicity in SH-SY5Y cells through preserving Akt/mTOR activity
por: Zhang, Huiyuan, et al.
Publicado: (2019)

SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway
por: Zhang, Meng, et al.
Publicado: (2018)

RhoA promotes osteoclastogenesis and regulates bone remodeling through mTOR-NFATc1 signaling
por: Wang, Jirong, et al.
Publicado: (2023)

Histone Deacetylase 4 Inhibition Reduces Rotenone-Induced Alpha-Synuclein Accumulation via Autophagy in SH-SY5Y Cells
por: Wang, Luxi, et al.
Publicado: (2023)

Cornin protects SH-SY5Y cells against oxygen and glucose deprivation-induced autophagy through the PI3K/Akt/mTOR pathway
por: Ding, Changling, et al.
Publicado: (2018)

Correction: RhoA promotes osteoclastogenesis and regulates bone remodeling through mTOR-NFATc1 signaling
por: Wang, Jirong, et al.
Publicado: (2023)

Idebenone-Activating Autophagic Degradation of α-Synuclein via Inhibition of AKT-mTOR Pathway in a SH-SY5Y-A53T Model of Parkinson's Disease: A Network Pharmacological Approach
por: He, Pei Kun, et al.
Publicado: (2021)

Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling
por: Chen, Xiangzheng, et al.
Publicado: (2016)

Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy
por: Zhang, Yuan, et al.
Publicado: (2022)

Ellagic Acid Prevents α-Synuclein Aggregation and Protects SH-SY5Y Cells from Aggregated α-Synuclein-Induced Toxicity via Suppression of Apoptosis and Activation of Autophagy
por: Ardah, Mustafa T, et al.
Publicado: (2021)

Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells
por: Sang, Jason C., et al.
Publicado: (2021)

Neuroprotective effects of genistein on SH-SY5Y cells overexpressing A53T mutant α-synuclein
por: Wu, Huan-Cheng, et al.
Publicado: (2018)

mTOR, autophagy, and reprogramming
por: Tang, Bor Luen
Publicado: (2014)

Salidroside attenuates hypoxia-induced pulmonary arterial smooth muscle cell proliferation and apoptosis resistance by upregulating autophagy through the AMPK-mTOR-ULK1 pathway
por: Gui, Di, et al.
Publicado: (2017)

Ndfip1 Prevents Rotenone-Induced Neurotoxicity and Upregulation of α-Synuclein in SH-SY5Y Cells
por: Liu, Xin, et al.
Publicado: (2021)

Mito-Tempo suppresses autophagic flux via the PI3K/Akt/mTOR signaling pathway in neuroblastoma SH-SY5Y cells
por: Mukem, Sirirak, et al.
Publicado: (2021)

mTOR Pathways in Cancer and Autophagy
por: Paquette, Mathieu, et al.
Publicado: (2018)

Inhibition of DNA Repair Protein Ku70 in High-Glucose Environment Aggravates the Neurotoxicity Induced by Bupivacaine in SH-SY5Y Cells
por: Ji, Zhong-Hua, et al.
Publicado: (2020)

Effects of Subtoxic Concentrations of Atrazine, Cypermethrin, and Vinclozolin on microRNA-Mediated PI3K/Akt/mTOR Signaling in SH-SY5Y Cells
por: Graziosi, Agnese, et al.
Publicado: (2022)

Neuroprotective Effect of Chebulagic Acid via Autophagy Induction in SH-SY5Y Cells
por: Kim, Hee Ju, et al.
Publicado: (2014)

Alpha-Synuclein and Calpains Disrupt SNARE-Mediated Synaptic Vesicle Fusion During Manganese Exposure in SH-SY5Y Cells
por: Wang, Can, et al.
Publicado: (2018)

Neuroprotective effect of chondroitin sulfate on SH-SY5Y cells overexpressing wild-type or A53T mutant α-synuclein
por: Ju, Chuanxia, et al.
Publicado: (2017)

Overexpression of alpha-synuclein promotes both cell proliferation and cell toxicity in human SH-SY5Y neuroblastoma cells
por: Rodríguez-Losada, Noela, et al.
Publicado: (2020)

The mTOR–Autophagy Axis and the Control of Metabolism
por: Deleyto-Seldas, Nerea, et al.
Publicado: (2021)

Inhibiting Autophagy Pathway of PI3K/AKT/mTOR Promotes Apoptosis in SK-N-SH Cell Model of Alzheimer's Disease
por: Pang, Yu, et al.
Publicado: (2022)

Effects of the autophagy modulators d-limonene and chloroquine on vimentin levels in SH-SY5Y cells
por: Gentile, Debora, et al.
Publicado: (2020)

Inhibition of Autophagy Negates Radiofrequency-Induced Adaptive Response in SH-SY5Y Neuroblastoma Cells
por: Sannino, Anna, et al.
Publicado: (2022)

Lupenone Protects Neuroblastoma SH-SY5y Cells Against Methamphetamine-Induced Apoptotic Cell Death via PI3K/Akt/mTOR Signaling Pathway
por: Lee, Hyun-Su, et al.
Publicado: (2020)

Observation of α-Synuclein Preformed Fibrils Interacting with SH-SY5Y Neuroblastoma Cell Membranes Using Scanning Ion Conductance Microscopy
por: Feng, Christina, et al.
Publicado: (2022)

The Degradation of TMEM166 by Autophagy Promotes AMPK Activation to Protect SH-SY5Y Cells Exposed to MPP(+)
por: Liao, Zhaozhong, et al.
Publicado: (2022)

The Impairments of α-Synuclein and Mechanistic Target of Rapamycin in Rotenone-Induced SH-SY5Y Cells and Mice Model of Parkinson’s Disease
por: Ramalingam, Mahesh, et al.
Publicado: (2019)

A Matrigel-based 3D construct of SH-SY5Y cells models the α-synuclein pathologies of Parkinson's disease
por: Li, Zhao-Feng, et al.
Publicado: (2022)

The Upstream Pathway of mTOR-Mediated Autophagy in Liver Diseases
por: Wang, Haojie, et al.
Publicado: (2019)

Liraglutide Attenuates Aβ42 Generation in APPswe/SH-SY5Y Cells Through the Regulation of Autophagy
por: Kong, Jingjing, et al.
Publicado: (2020)

Isoquercitrin induces apoptosis and autophagy in hepatocellular carcinoma cells via AMPK/mTOR/p70S6K signaling pathway
por: Shui, Liyan, et al.
Publicado: (2020)

Fingolimod suppresses neuronal autophagy through the mTOR/p70S6K pathway and alleviates ischemic brain damage in mice
por: Li, Xiao, et al.
Publicado: (2017)

Eugenol Attenuates Cerebral Ischemia-Reperfusion Injury by Enhancing Autophagy via AMPK-mTOR-P70S6K Pathway
por: Sun, Xiaowei, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_hj441jj8mo7h762qi099iqbi5v