A Receptor Model With Binding Affinity, Activation Efficacy, and Signal Amplification Parameters for Complex Fractional Response Versus Occupancy Data

In quantitative pharmacology, multi-parameter receptor models are needed to account for the complex nonlinear relationship between fractional occupancy and response that can occur due to the intermixing of the effects of partial receptor activation and post-receptor signal amplification. Here, a gen...

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Detalles Bibliográficos
Autor principal: Buchwald, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580154/
https://www.ncbi.nlm.nih.gov/pubmed/31244653
http://dx.doi.org/10.3389/fphar.2019.00605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580154/
https://www.ncbi.nlm.nih.gov/pubmed/31244653
http://dx.doi.org/10.3389/fphar.2019.00605

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