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In the absence of UCP1-mediated diet-induced thermogenesis, obesity is augmented even in the obesity-resistant 129S mouse strain

The attractive tenet that recruitment and activation of brown adipose tissue (BAT) and uncoupling protein 1 (UCP1) could counteract the development of obesity and its comorbidities in humans has been experimentally corroborated mainly by experiments demonstrating that UCP1-ablated mice on a C57Bl/6...

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Detalles Bibliográficos
Autores principales: Luijten, Ineke H. N., Feldmann, Helena M., von Essen, Gabriella, Cannon, Barbara, Nedergaard, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580168/
https://www.ncbi.nlm.nih.gov/pubmed/30807213
http://dx.doi.org/10.1152/ajpendo.00020.2019