Blocking podoplanin suppresses growth and pulmonary metastasis of human malignant melanoma

BACKGROUND: Podoplanin (PDPN), a transmembrane O-glycoprotein, is up-regulated in many tumors and is involved in tumor metastasis and malignant progression. In previous studies, we generated a functional blocking monoclonal antibody (mAb, SZ168) against the extracellular domain of human PDPN. This s...

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Detalles Bibliográficos
Autores principales: Xu, Mengqiao, Wang, Xia, Pan, Yanfang, Zhao, Xingpeng, Yan, Bin, Ruan, Changgeng, Xia, Lijun, Zhao, Yiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580467/
https://www.ncbi.nlm.nih.gov/pubmed/31208371
http://dx.doi.org/10.1186/s12885-019-5808-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580467/
https://www.ncbi.nlm.nih.gov/pubmed/31208371
http://dx.doi.org/10.1186/s12885-019-5808-9

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