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SU5416 does not attenuate early RV angiogenesis in the murine chronic hypoxia PH model

BACKGROUND: Right ventricular (RV) angiogenesis has been associated with adaptive myocardial remodeling in pulmonary hypertension (PH), though molecular regulators are poorly defined. Endothelial cell VEGFR-2 is considered a “master regulator” of angiogenesis in other models, and the small molecule...

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Detalles Bibliográficos
Autores principales: Peloquin, Grace L., Johnston, Laura, Damarla, Mahendra, Damico, Rachel L., Hassoun, Paul M., Kolb, Todd M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580559/
https://www.ncbi.nlm.nih.gov/pubmed/31208454
http://dx.doi.org/10.1186/s12931-019-1079-x