Expansion of IL-23 receptor bearing TNFR2+ T cells is associated with molecular resistance to anti-TNF therapy in Crohn’s disease

OBJECTIVE: Anti-tumour necrosis factor (TNF) antibodies are successfully used for treatment of Crohn’s disease. Nevertheless, approximately 40% of patients display failure to anti-TNF therapy. Here, we characterised molecular mechanisms that are associated with endoscopic resistance to anti-TNF ther...

Descripción completa

Detalles Bibliográficos
Autores principales: Schmitt, Heike, Billmeier, Ulrike, Dieterich, Walburga, Rath, Timo, Sonnewald, Sophia, Reid, Stephen, Hirschmann, Simon, Hildner, Kai, Waldner, Maximilian J, Mudter, Jonas, Hartmann, Arndt, Grützmann, Robert, Neufert, Clemens, Münster, Tino, Neurath, Markus F, Atreya, Raja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Inflammatory Bowel Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580782/
https://www.ncbi.nlm.nih.gov/pubmed/29848778
http://dx.doi.org/10.1136/gutjnl-2017-315671

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580782/
https://www.ncbi.nlm.nih.gov/pubmed/29848778
http://dx.doi.org/10.1136/gutjnl-2017-315671

Ejemplares similares