A massively parallel 3′ UTR reporter assay reveals relationships between nucleotide content, sequence conservation, and mRNA destabilization

Compared to coding sequences, untranslated regions of the transcriptome are not well conserved, and functional annotation of these sequences is challenging. Global relationships between nucleotide composition of 3′ UTR sequences and their sequence conservation have been appreciated since mammalian g...

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Detalles Bibliográficos
Autores principales: Litterman, Adam J., Kageyama, Robin, Le Tonqueze, Olivier, Zhao, Wenxue, Gagnon, John D., Goodarzi, Hani, Erle, David J., Ansel, K. Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581050/
https://www.ncbi.nlm.nih.gov/pubmed/31152051
http://dx.doi.org/10.1101/gr.242552.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581050/
https://www.ncbi.nlm.nih.gov/pubmed/31152051
http://dx.doi.org/10.1101/gr.242552.118

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