Beta-binomial modeling of CRISPR pooled screen data identifies target genes with greater sensitivity and fewer false negatives

The simplicity and cost-effectiveness of CRISPR technology have made high-throughput pooled screening approaches accessible to virtually any laboratory. Analyzing the large sequencing data derived from these studies, however, still demands considerable bioinformatics expertise. Various methods have...

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Detalles Bibliográficos
Autores principales: Jeong, Hyun-Hwan, Kim, Seon Young, Rousseaux, Maxime W.C., Zoghbi, Huda Y., Liu, Zhandong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581060/
https://www.ncbi.nlm.nih.gov/pubmed/31015259
http://dx.doi.org/10.1101/gr.245571.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581060/
https://www.ncbi.nlm.nih.gov/pubmed/31015259
http://dx.doi.org/10.1101/gr.245571.118

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