Ultra-high-dose methylcobalamin in amyotrophic lateral sclerosis: a long-term phase II/III randomised controlled study

OBJECTIVE: To evaluate the efficacy and safety of intramuscular ultra-high-dose methylcobalamin in patients with amyotrophic lateral sclerosis (ALS). METHODS: 373 patients with ALS (El Escorial definite or probable; laboratory-supported probable; duration ≤36 months) were randomly assigned to placeb...

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Detalles Bibliográficos
Autores principales: Kaji, Ryuji, Imai, Takashi, Iwasaki, Yasuo, Okamoto, Koichi, Nakagawa, Masanori, Ohashi, Yasuo, Takase, Takao, Hanada, Takahisa, Shimizu, Hiroki, Tashiro, Kunio, Kuzuhara, Shigeki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Neuromuscular
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581107/
https://www.ncbi.nlm.nih.gov/pubmed/30636701
http://dx.doi.org/10.1136/jnnp-2018-319294

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581107/
https://www.ncbi.nlm.nih.gov/pubmed/30636701
http://dx.doi.org/10.1136/jnnp-2018-319294

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