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Ultra-high-dose methylcobalamin in amyotrophic lateral sclerosis: a long-term phase II/III randomised controlled study

OBJECTIVE: To evaluate the efficacy and safety of intramuscular ultra-high-dose methylcobalamin in patients with amyotrophic lateral sclerosis (ALS). METHODS: 373 patients with ALS (El Escorial definite or probable; laboratory-supported probable; duration ≤36 months) were randomly assigned to placeb...

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Detalles Bibliográficos
Autores principales:	Kaji, Ryuji, Imai, Takashi, Iwasaki, Yasuo, Okamoto, Koichi, Nakagawa, Masanori, Ohashi, Yasuo, Takase, Takao, Hanada, Takahisa, Shimizu, Hiroki, Tashiro, Kunio, Kuzuhara, Shigeki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2019
Materias:	Neuromuscular
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581107/ https://www.ncbi.nlm.nih.gov/pubmed/30636701 http://dx.doi.org/10.1136/jnnp-2018-319294

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