Heavy-tailed prior distributions for sequence count data: removing the noise and preserving large differences

MOTIVATION: In RNA-seq differential expression analysis, investigators aim to detect those genes with changes in expression level across conditions, despite technical and biological variability in the observations. A common task is to accurately estimate the effect size, often in terms of a logarith...

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Detalles Bibliográficos
Autores principales: Zhu, Anqi, Ibrahim, Joseph G, Love, Michael I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581436/
https://www.ncbi.nlm.nih.gov/pubmed/30395178
http://dx.doi.org/10.1093/bioinformatics/bty895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581436/
https://www.ncbi.nlm.nih.gov/pubmed/30395178
http://dx.doi.org/10.1093/bioinformatics/bty895

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