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Heavy-tailed prior distributions for sequence count data: removing the noise and preserving large differences
MOTIVATION: In RNA-seq differential expression analysis, investigators aim to detect those genes with changes in expression level across conditions, despite technical and biological variability in the observations. A common task is to accurately estimate the effect size, often in terms of a logarith...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581436/ https://www.ncbi.nlm.nih.gov/pubmed/30395178 http://dx.doi.org/10.1093/bioinformatics/bty895 |