RNAi-based functional selection identifies novel cell migration determinants dependent on PI3K and AKT pathways

Lentiviral short hairpin RNA (shRNA)-mediated genetic screening is a powerful tool for identifying loss-of-function phenotype in mammalian cells. Here, we report the identification of 91 cell migration-regulating genes using unbiased genome-wide functional genetic selection. Individual knockdown or...

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Detalles Bibliográficos
Autores principales: Seo, Minchul, Lee, Shinrye, Kim, Jong-Heon, Lee, Won-Ha, Hu, Guang, Elledge, Stephen J., Suk, Kyoungho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581447/
https://www.ncbi.nlm.nih.gov/pubmed/25347953
http://dx.doi.org/10.1038/ncomms6217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581447/
https://www.ncbi.nlm.nih.gov/pubmed/25347953
http://dx.doi.org/10.1038/ncomms6217

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