Pyruvate kinase M2, but not M1, allele maintains immature metabolic states of murine embryonic stem cells

The M2 isoform of pyruvate kinase, the final rate-limiting enzyme of aerobic glycolysis, is expressed during embryonic development. In contrast, the M1 isoform is expressed in differentiated cells due to alternative splicing. Here we investigated murine embryonic stem cells (ESCs) with Pkm1 or Pkm2...

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Detalles Bibliográficos
Autores principales: Konno, Masamitsu, Ishii, Hideshi, Koseki, Jun, Tanuma, Nobuhiro, Nishida, Naohiro, Kawamoto, Koichi, Nishimura, Tatsunori, Nakata, Asuka, Matsui, Hidetoshi, Noguchi, Kozou, Ozaki, Miyuki, Noguchi, Yuko, Shima, Hiroshi, Gotoh, Noriko, Nagano, Hiroaki, Doki, Yuichiro, Mori, Masaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society for Regenerative Medicine 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581773/
https://www.ncbi.nlm.nih.gov/pubmed/31245442
http://dx.doi.org/10.1016/j.reth.2015.01.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581773/
https://www.ncbi.nlm.nih.gov/pubmed/31245442
http://dx.doi.org/10.1016/j.reth.2015.01.001

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