Breakage-Fusion-Bridge Events Trigger Complex Genome Rearrangements and Amplifications in Developmentally Arrested T Cell Lymphomas

To reveal the relative contribution of the recombination activating gene (RAG)1/2 nuclease to lymphomagenesis, we conducted a genome-wide analysis of T cell lymphomas from p53-deficient mice expressing or lacking RAG2. We found that while p53(−/−) lymphoblastic T cells harbor primarily ectopic DNA d...

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Detalles Bibliográficos
Autores principales: Bianchi, Joy J., Murigneux, Valentine, Bedora-Faure, Marie, Lescale, Chloé, Deriano, Ludovic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581794/
https://www.ncbi.nlm.nih.gov/pubmed/31167132
http://dx.doi.org/10.1016/j.celrep.2019.05.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581794/
https://www.ncbi.nlm.nih.gov/pubmed/31167132
http://dx.doi.org/10.1016/j.celrep.2019.05.014

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