Phosphorylation of FANCD2 Inhibits the FANCD2/FANCI Complex and Suppresses the Fanconi Anemia Pathway in the Absence of DNA Damage

Interstrand crosslinks (ICLs) of the DNA helix are a deleterious form of DNA damage. ICLs can be repaired by the Fanconi anemia pathway. At the center of the pathway is the FANCD2/FANCI complex, recruitment of which to DNA is a critical step for repair. After recruitment, monoubiquitination of both...

Descripción completa

Detalles Bibliográficos
Autores principales: Lopez-Martinez, David, Kupculak, Marian, Yang, Di, Yoshikawa, Yasunaga, Liang, Chih-Chao, Wu, Ronghu, Gygi, Steven P., Cohn, Martin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581795/
https://www.ncbi.nlm.nih.gov/pubmed/31167143
http://dx.doi.org/10.1016/j.celrep.2019.05.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581795/
https://www.ncbi.nlm.nih.gov/pubmed/31167143
http://dx.doi.org/10.1016/j.celrep.2019.05.003

Ejemplares similares