Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies

Accurate prediction of drug-drug interactions (DDI) is a challenging task in drug discovery and development. It requires determination of enzyme inhibition in vitro which is highly system-dependent for many compounds. The aim of this study was to investigate whether the determination of intracellula...

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Detalles Bibliográficos
Autores principales: Treyer, Andrea, Ullah, Mohammed, Parrott, Neil, Molitor, Birgit, Fowler, Stephen, Artursson, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581936/
https://www.ncbi.nlm.nih.gov/pubmed/31214810
http://dx.doi.org/10.1208/s12248-019-0344-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581936/
https://www.ncbi.nlm.nih.gov/pubmed/31214810
http://dx.doi.org/10.1208/s12248-019-0344-8

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