Synaptic FUS Localization During Motoneuron Development and Its Accumulation in Human ALS Synapses

Mutations in the fused in Sarcoma (FUS) gene induce cytoplasmic FUS aggregations, contributing to the neurodegenerative disease amyotrophic lateral sclerosis (ALS) in certain cases. While FUS is mainly a nuclear protein involved in transcriptional processes with limited cytoplasmic functions, it sho...

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Detalles Bibliográficos
Autores principales: Deshpande, Dhruva, Higelin, Julia, Schoen, Michael, Vomhof, Thomas, Boeckers, Tobias M., Demestre, Maria, Michaelis, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582137/
https://www.ncbi.nlm.nih.gov/pubmed/31244613
http://dx.doi.org/10.3389/fncel.2019.00256

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582137/
https://www.ncbi.nlm.nih.gov/pubmed/31244613
http://dx.doi.org/10.3389/fncel.2019.00256

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