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Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk

Genetic studies of complex traits in animals have been hindered by the need to generate, maintain, and phenotype large panels of recombinant lines. We developed a new method, C. elegans eXtreme Quantitative Trait Locus (ceX-QTL) mapping, that overcomes this obstacle via bulk selection on millions of...

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Autores principales: Burga, Alejandro, Ben-David, Eyal, Lemus Vergara, Tzitziki, Boocock, James, Kruglyak, Leonid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582151/
https://www.ncbi.nlm.nih.gov/pubmed/31213597
http://dx.doi.org/10.1038/s41467-019-10636-9
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author Burga, Alejandro
Ben-David, Eyal
Lemus Vergara, Tzitziki
Boocock, James
Kruglyak, Leonid
author_facet Burga, Alejandro
Ben-David, Eyal
Lemus Vergara, Tzitziki
Boocock, James
Kruglyak, Leonid
author_sort Burga, Alejandro
collection PubMed
description Genetic studies of complex traits in animals have been hindered by the need to generate, maintain, and phenotype large panels of recombinant lines. We developed a new method, C. elegans eXtreme Quantitative Trait Locus (ceX-QTL) mapping, that overcomes this obstacle via bulk selection on millions of unique recombinant individuals. We use ceX-QTL to map a drug resistance locus with high resolution. We also map differences in gene expression in live worms and discovered that mutations in the co-chaperone sti-1 upregulate the transcription of HSP-90. Lastly, we use ceX-QTL to map loci that influence fitness genome-wide confirming previously reported causal variants and uncovering new fitness loci. ceX-QTL is fast, powerful and cost-effective, and will accelerate the study of complex traits in animals.
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spelling pubmed-65821512019-06-24 Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk Burga, Alejandro Ben-David, Eyal Lemus Vergara, Tzitziki Boocock, James Kruglyak, Leonid Nat Commun Article Genetic studies of complex traits in animals have been hindered by the need to generate, maintain, and phenotype large panels of recombinant lines. We developed a new method, C. elegans eXtreme Quantitative Trait Locus (ceX-QTL) mapping, that overcomes this obstacle via bulk selection on millions of unique recombinant individuals. We use ceX-QTL to map a drug resistance locus with high resolution. We also map differences in gene expression in live worms and discovered that mutations in the co-chaperone sti-1 upregulate the transcription of HSP-90. Lastly, we use ceX-QTL to map loci that influence fitness genome-wide confirming previously reported causal variants and uncovering new fitness loci. ceX-QTL is fast, powerful and cost-effective, and will accelerate the study of complex traits in animals. Nature Publishing Group UK 2019-06-18 /pmc/articles/PMC6582151/ /pubmed/31213597 http://dx.doi.org/10.1038/s41467-019-10636-9 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Burga, Alejandro
Ben-David, Eyal
Lemus Vergara, Tzitziki
Boocock, James
Kruglyak, Leonid
Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk
title Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk
title_full Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk
title_fullStr Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk
title_full_unstemmed Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk
title_short Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk
title_sort fast genetic mapping of complex traits in c. elegans using millions of individuals in bulk
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582151/
https://www.ncbi.nlm.nih.gov/pubmed/31213597
http://dx.doi.org/10.1038/s41467-019-10636-9
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