Cargando…

TET Upregulation Leads to 5-Hydroxymethylation Enrichment in Hepatoblastoma

Hepatoblastoma is an embryonal liver tumor carrying few genetic alterations. We previously disclosed in hepatoblastomas a genome-wide methylation dysfunction, characterized by hypermethylation at specific CpG islands, in addition to a low-level hypomethylation pattern in non-repetitive intergenic se...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rivas, Maria Prates, Aguiar, Talita Ferreira Marques, Fernandes, Gustavo Ribeiro, Caires-Júnior, Luiz Carlos, Goulart, Ernesto, Telles-Silva, Kayque Alves, Cypriano, Monica, de Toledo, Silvia Regina Caminada, Rosenberg, Carla, Carraro, Dirce Maria, da Costa, Cecilia Maria Lima, da Cunha, Isabela Werneck, Krepischi, Ana Cristina Victorino
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582250/ https://www.ncbi.nlm.nih.gov/pubmed/31249594 http://dx.doi.org/10.3389/fgene.2019.00553

Ejemplares similares

Copy Number Alterations in Hepatoblastoma: Literature Review and a Brazilian Cohort Analysis Highlight New Biological Pathways
por: Barros, Juliana Sobral, et al.
Publicado: (2021)

Insights Into the Somatic Mutation Burden of Hepatoblastomas From Brazilian Patients
por: Aguiar, Talita Ferreira Marques, et al.
Publicado: (2020)

DNA methylation landscape of hepatoblastomas reveals arrest at early stages of liver differentiation and cancer-related alterations
por: Maschietto, Mariana, et al.
Publicado: (2016)

High-Resolution Magic-Angle-Spinning NMR in Revealing Hepatoblastoma Hallmarks
por: Tasic, Ljubica, et al.
Publicado: (2022)

Hippocampal TET1 and TET2 Expression and DNA Hydroxymethylation Are Affected by Physical Exercise in Aged Mice
por: Jessop, Peter, et al.
Publicado: (2018)

Unraveling the Genetic Architecture of Hepatoblastoma Risk: Birth Defects and Increased Burden of Germline Damaging Variants in Gastrointestinal/Renal Cancer Predisposition and DNA Repair Genes
por: Aguiar, Talita, et al.
Publicado: (2022)

Mutational spectrum of the APC and MUTYH genes and genotype–phenotype correlations in Brazilian FAP, AFAP, and MAP patients
por: Torrezan, Giovana Tardin, et al.
Publicado: (2013)

Genome-wide profiling of copy number alterations in triple-negative breast cancer identifies a region at 19p13 associated with lymph node metastasis
por: Fidalgo, Felipe, et al.
Publicado: (2013)

A novel SYBR-based duplex qPCR for the detection of gene dosage: detection of an APC large deletion in a familial adenomatous polyposis patient with an unusual phenotype
por: Torrezan, Giovana Tardin, et al.
Publicado: (2012)

The Profiles of Tet-Mediated DNA Hydroxymethylation in Human Gliomas
por: Brągiel-Pieczonka, Aneta, et al.
Publicado: (2022)

Insights into DNA hydroxymethylation in the honeybee from in-depth analyses of TET dioxygenase
por: Wojciechowski, Marek, et al.
Publicado: (2014)

TET1-Mediated Hydroxymethylation Facilitates Hypoxic Gene Induction in Neuroblastoma
por: Mariani, Christopher J., et al.
Publicado: (2014)

TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice
por: Moyon, Sarah, et al.
Publicado: (2021)

TET-mediated DNA hydroxymethylation is negatively influenced by the PARP-dependent PARylation
por: Tolić, Anja, et al.
Publicado: (2022)

The role of DNA hydroxymethylation and TET enzymes in placental development and pregnancy outcome
por: Vasconcelos, Sara, et al.
Publicado: (2023)

Methamphetamine Induces TET1- and TET3-Dependent DNA Hydroxymethylation of Crh and Avp Genes in the Rat Nucleus Accumbens
por: Jayanthi, Subramaniam, et al.
Publicado: (2017)

Epigenetic regulation of intestinal stem cells by Tet1-mediated DNA hydroxymethylation
por: Kim, Rinho, et al.
Publicado: (2016)

TET2 is involved in DNA hydroxymethylation, cell proliferation and inflammatory response in keratinocytes
por: Liu, Xinxin, et al.
Publicado: (2020)

TET1 and 5-Hydroxymethylation Preserve the Stem Cell State of Mouse Trophoblast
por: Senner, Claire E., et al.
Publicado: (2020)

Applied Hepatic Bioengineering: Modeling the Human Liver Using Organoid and Liver-on-a-Chip Technologies
por: Telles-Silva, Kayque Alves, et al.
Publicado: (2022)

Olaparib Inhibits Tumor Growth of Hepatoblastoma in Patient‐Derived Xenograft Models
por: Johnston, Michael Edward, et al.
Publicado: (2021)

Lymphovascular invasion and histologic grade are associated with specific genomic profiles in invasive carcinomas of the breast
por: Fidalgo, Felipe, et al.
Publicado: (2014)

Role of TET Dioxygenases and DNA Hydroxymethylation in Bisphenols-Stimulated Proliferation of Breast Cancer Cells
por: Li, Zhe, et al.
Publicado: (2020)

A genomic case study of desmoplastic small round cell tumor: comprehensive analysis reveals insights into potential therapeutic targets and development of a monitoring tool for a rare and aggressive disease
por: Ferreira, Elisa Napolitano, et al.
Publicado: (2016)

Epigenetic Modifications in the Biology of Nonalcoholic Fatty Liver Disease: The Role of DNA Hydroxymethylation and TET Proteins
por: Pirola, Carlos J., et al.
Publicado: (2015)

Genomic and epigenomic analysis of high-risk prostate cancer reveals changes in hydroxymethylation and TET1
por: Spans, Lien, et al.
Publicado: (2016)

Tet-mediated DNA hydroxymethylation regulates retinal neurogenesis by modulating cell-extrinsic signaling pathways
por: Seritrakul, Pawat, et al.
Publicado: (2017)

TET-Catalyzed 5-Hydroxymethylation Precedes HNF4A Promoter Choice during Differentiation of Bipotent Liver Progenitors
por: Ancey, Pierre-Benoit, et al.
Publicado: (2017)

TET1 promotes fatty acid oxidation and inhibits NAFLD progression by hydroxymethylation of PPARα promoter
por: Wang, Jingjie, et al.
Publicado: (2020)

TET2 Overexpression in Chronic Lymphocytic Leukemia Is Unrelated to the Presence of TET2 Variations
por: Hernández-Sánchez, María, et al.
Publicado: (2014)

Antidepressant-Like Effect of Sodium Butyrate is Associated with an Increase in TET1 and in 5-Hydroxymethylation Levels in the Bdnf Gene
por: Wei, Ya Bin, et al.
Publicado: (2015)

Downregulation of TET1 Promotes Bladder Cancer Cell Proliferation and Invasion by Reducing DNA Hydroxymethylation of AJAP1
por: Yan, Yi-lin, et al.
Publicado: (2020)

α5 integrin regulates hepatic tight junctions through SRC-TET1-mediated DNA hydroxymethylation
por: Ma, Yuejiao, et al.
Publicado: (2022)

TET2 is recruited by CREB to promote Cebpb, Cebpa, and Pparg transcription by facilitating hydroxymethylation during adipocyte differentiation
por: Liu, Yunjia, et al.
Publicado: (2023)

RAS mutations vary between lesions in synchronous primary colorectal cancer: testing only one lesion is not sufficient to guide anti-EGFR treatment decisions
por: de Macedo, Mariana Petaccia, et al.
Publicado: (2015)

TET1 upregulation drives cancer cell growth through aberrant enhancer hydroxymethylation of HMGA2 in hepatocellular carcinoma
por: Shirai, Kiyokazu, et al.
Publicado: (2021)

Family-based whole-exome sequencing identifies rare variants potentially related to cutaneous melanoma predisposition in Brazilian melanoma-prone families
por: Fidalgo, Felipe, et al.
Publicado: (2022)

Upregulation of CRABP2 by TET1-mediated DNA hydroxymethylation attenuates mitochondrial apoptosis and promotes oxaliplatin resistance in gastric cancer
por: Tang, Xiaolong, et al.
Publicado: (2022)

Tet-dependent 5-hydroxymethyl-Cytosine modification of mRNA regulates the axon guidance genes robo2 and slit in Drosophila
por: Singh, Badri Nath, et al.
Publicado: (2023)

Association of Folate and Vitamins Involved in the 1-Carbon Cycle with Polymorphisms in the Methylenetetrahydrofolate Reductase Gene (MTHFR) and Global DNA Methylation in Patients with Colorectal Cancer
por: Ferrari, Ariana, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_uic9l09v124rtovg0omp9me9hs