Increased versatility despite reduced molecular complexity: evolution, structure and function of metazoan splicing factor PRPF39

In the yeast U1 snRNP the Prp39/Prp42 heterodimer is essential for early steps of spliceosome assembly. In metazoans no Prp42 ortholog exists, raising the question how the heterodimer is functionally substituted. Here we present the crystal structure of murine PRPF39, which forms a homodimer. Struct...

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Detalles Bibliográficos
Autores principales: De Bortoli, Francesca, Neumann, Alexander, Kotte, Ana, Timmermann, Bernd, Schüler, Thomas, Wahl, Markus C, Loll, Bernhard, Heyd, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582350/
https://www.ncbi.nlm.nih.gov/pubmed/30949712
http://dx.doi.org/10.1093/nar/gkz243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582350/
https://www.ncbi.nlm.nih.gov/pubmed/30949712
http://dx.doi.org/10.1093/nar/gkz243

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