Developing an Antibody–Drug Conjugate Approach to Selective Inhibition of an Extracellular Protein

Antibody–drug conjugates (ADCs) are a growing class of therapeutics that harness the specificity of antibodies and the cell‐killing potency of small‐molecule drugs. Beyond cytotoxics, there are few examples of the application of an ADC approach to difficult drug discovery targets. Here, we present t...

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Detalles Bibliográficos
Autores principales: Love, Elizabeth A., Sattikar, Afrah, Cook, Hannah, Gillen, Kevin, Large, Jonathan M., Patel, Seema, Matthews, David, Merritt, Andy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582441/
https://www.ncbi.nlm.nih.gov/pubmed/30507063
http://dx.doi.org/10.1002/cbic.201800623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582441/
https://www.ncbi.nlm.nih.gov/pubmed/30507063
http://dx.doi.org/10.1002/cbic.201800623

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