Pharmacological profiling of a dual FAK/IGF-1R kinase inhibitor TAE226 in cellular and in vivo tumor models

OBJECTIVE: A dual inhibitor of focal adhesion kinase (FAK) and insulin-like growth factor 1 receptor (IGF-1R), TAE226, was evaluated in a panel of cancer cell lines, MIA PaCa-2 human pancreatic tumor and 4T1 murine breast tumor models. The profiling data were generated during the drug discovery rese...

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Detalles Bibliográficos
Autores principales: Fukami, Shigemi, Tomioka, Daisaku, Murakami, Yutaka, Honda, Toshiyuki, Hatakeyama, Shinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582604/
https://www.ncbi.nlm.nih.gov/pubmed/31215459
http://dx.doi.org/10.1186/s13104-019-4389-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582604/
https://www.ncbi.nlm.nih.gov/pubmed/31215459
http://dx.doi.org/10.1186/s13104-019-4389-7

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